Entirely North West


Cheshire-based AMR Centre signs exciting Trans-Atlantic deal

THE AMR Centre, the Cheshire-based research and development facility for new antibiotics and diagnostics, has signed a co-development deal with a US biotech company

Cheshire-based AMR Centre signs exciting Trans-Atlantic deal

The Alderley Park-based organisation’s partnership with Microbiotix Inc,, a Massachusetts clinical-stage drug development company, will accelerate the development of Microbiotix’s lead bacterial virulence drug candidate.

As part of this agreement, Microbiotix and the AMR Centre will combine resources and leverage their antimicrobial R&D expertise to accelerate the development of Microbiotix's T3SS (type III secretion system) inhibitor project, which was awarded up to $3.2 million, based on successful progression through milestones, from CARB-X (Combating Antibiotic-Resistant Bacteria Accelerator) in March 2017. 

Under this new agreement, the AMR Centre will provide up to $1.1m of technical support including over $600,000 of project funding, alongside $1.6m of initial CARB-X funding, to identify a drug candidate to take into clinical trials.

"We are pleased to be working with Microbiotix to help address the critical unmet need for therapies targeting drug resistant Gram-negative bacteria."
Dr Pete Jackson, Executive Director of AMR Centre

"This agreement with the AMR Centre will significantly accelerate our ability to deliver a pre-clinical candidate," said Terry Bowlin, PhD, President & CEO, Microbiotix. "We believe our T3SS inhibitors have great potential to help critically ill patients infected with drug resistant P. aeruginosa.

“Almost one-third of clinical isolates from these patients are resistant to three or more antibiotics, leading to treatment failures and increased mortality. Our novel inhibitors of the type III secretion system (T3SS) of Pseudomonas aeruginosa, have been shown to reverse the pathogen's disruption of the host innate immune response to infection and are not subject to efflux or existing antibiotic resistance mechanisms."

Dr Pete Jackson, Executive Director of the AMR Centre, said: “"We are pleased to be working with Microbiotix to help address the critical unmet need for therapies targeting drug resistant Gram-negative bacteria.

“As a CARB-X alliance partner we are pleased to be inputting our resources alongside those of CARB-X and Microbiotix, into this exciting trans-Atlantic program.  This is very much a co-development and as such our UK based scientists are actively working on what candidates to take forward. We believe that this innovative project, which targets a World Health Organisation Priority 1 and ESKAPE pathogen, has the potential to reduce the threat of antimicrobial resistance."

DISCLAIMER: The statements, opinions, views and advice expressed in this article are those of the author/organisation and not of ENTIRELY. This article should represent information correct at the time of publication however whilst every care has been taken to present up-to-date and accurate information, we cannot guarantee that inaccuracies will not occur. ENTIRELY will not be held responsible for any claim, loss, damage or inconvenience caused as a result of any information within this article or any information accessed through this site. The content of any organisations websites which you link to from ENTIRELY are entirely out of the control of ENTIRELY, and you proceed at your own risk. These links are provided purely for your convenience and do not imply any endorsement of or association with any products, services, content, information or materials offered by or accessible to you at the organisations site.

Get The Entirely Weekly Brief In Your Inbox

Datamere Software Solutions

Datamere Software Solutions is an award-winning development company that offers a complete downstream package for gas suppliers. Established in 1998, Datamere created its market leading Gas Management System which offers a modular approach for portfolios of varying sizes.The company has also created bespoke software solutions for hospitality, healthcare and HR industries and is currently working on the development of GMS V4 and GENUS.


Virtual PA HR Services

Behind every successful business owner, consultant or freelancer is a team of support staff making sure that everything runs like clockwork. I offer a range of support services that will help your business do just that.By using Virtuelle's professional, flexible and affordable business support, all the day-to-day things that take up your time and energy are taken care of, so you can concentrate on what really matters to you running and growing a successful business.


Founded in 1981, JMC IT is an award-winning IT support partner based in Agecroft, Salford.

Stonehouse Logic

StoneHouse Logic provides IT systems that resolve the limitations and frustrations our clients are faced with, as well as offering services and software that maximise their productivity and profitability. \r\n

The Config Team

The Config Team -SAP Logistics and Warehouse Management Specialists - was founded in 1994. With its head consultant office based in Skelmersdale, the successful solutions it has delivered to globally respected names give it a reputation as a leading authority in SAP Logistics implementation.